Category Archives: Sexual Health

What are the symptoms of some of the common STDs?

Many common sexually transmitted diseases (STDs) share the same or very similar symptoms. These include:

  • Abnormal discharge
  • Painful and/or frequent urination
  • Pain during sexual intercourse
  • Itching, irritation or pain in the genital area
  • Small lumps or sores in the genital area

Of course, many common STDs also don’t cause any symptoms at all! For example, for chlamydia, only an estimated 10% of infected males show symptoms and 5-30% of infected females (1). This is why routine testing is very important to detect, treat, and prevent the spread of STDs. Our easy-to-use at-home sample collection kits make STD testing even simpler. If you are concerned about a recent potential exposure, take an STD test today.

Abnormal discharge:
Chlamydia, gonorrhea, and trichomoniasis can all cause abnormal discharge from the vagina in females and penis in males. This is typically a yellowish discharge in females and a white, cloudy or watery discharge in males. Sometimes the discharge can have a slightly green tinge and also have an unpleasant smell.

Non-STD health issues can also cause abnormal discharges, including urinary tract infections and yeast infections (2). Taking a simple STD test is an easy way to rule out a potential STD.

Painful and/or frequent urination:
Chlamydia, gonorrhea, trichomoniasis, and herpes are all associated with pain while urinating (dysuria). But once again, many non-STD health issues can also cause dysuria, including urinary tract infections, yeast infections, urethritis, certain prostate conditions, bladder and kidney stones, and certain medications (3).

Frequent urination is another common symptom of STDs, but can also be caused by kidney disease, urinary tract infection, pregnancy, prostate problems, and diabetes among other things (4).

Pain during sexual intercourse:
Chlamydia, gonorrhea, trichomoniasis, and herpes can also cause pain during sexual intercourse. Non-STD health issues in females that can also cause painful sex include vaginismus, vaginal infections, endometriosis, menopause, pelvic inflammatory disease (which can itself be a complication of an STD) (5). In males, other causes of painful sex include Peyronie’s disease, a tight foreskin, or prostatitis (6).

Itching, irritation, or pain in the genital area
Chlamydia, trichomoniasis, and herpes can cause discomfort in the genital area, particularly in females. This may be just mild irritation or severe itching and pain. Other causes of irritation include yeast infection and bacterial vaginosis in females, jock itch in males, and allergies in both genders. Sweating, tight clothing, and certain substances (e.g. soap) can also contribute to itchy genitals (7).

Small lumps or sores in the genital area
Syphilis, herpes, and human papillomavirus (HPV) are all associated with skin lumps and sores in and around the genitals.

For syphilis, a skin lesion known as a chancre occurs during primary infection. It can be a single painless chancre, or multiple painful and tender chancres (8).

Genital herpes can cause a patch of small red or white bumps, which are often painful. These pus-filled sores eventually burst to leave an ulcer-like sore on the skin (9).

HPV can cause warts in the genital area. These can be flat lesions, small cauliflower-like bumps, or tiny stem-like protrusions (10).

References:
1. Farley TA, Cohen DA, & Elkins W (2003). Asymptomatic sexually transmitted diseases: the case for screening. Prev Med, 36 (4), 502-509.
2. Barad DH (2020). Vaginal Discharge. Merck Manual Consumer Version.
3. Michels TC, Sands JE (2015). Dysuria: Evaluation and Differential Diagnosis in Adults. Am Fam Physician. 92 (9), 778-788.
4. Maddukuri G (2021). Excessive or Frequent Urination. Merck Manual Consumer Version.
5. Why Does it Hurt When I Have Sex? American Society for Reproductive Medicine.
6. Why does sex hurt? NHS. Reviewed May 2021.
7. 8 reasons your groin itches and how to get relief. American Academy of Dermatology Association.
8. Kent ME & Romanelli F (2008). Reexamining syphilis: an update on epidemiology, clinical manifestations, and management. Ann Pharmacother, 42 (2), 226-236.
9. Genital Herpes – CDC Fact Sheet (Detailed). CDC. Reviewed July 2021.
10. Genital HPV Infection – Fact Sheet. CDC. Reviewed January 2021.

How is HIV treated?

There is no cure for HIV. However, antiretroviral therapy (ART) is a very effective treatment to prevent the progression of HIV and to prevent the transmission of HIV to others. It enables HIV-positive individuals to live relatively normal, healthy lives (1).

What is ART?
ART is a life-long daily treatment that must be strictly followed. It is a combination of different HIV medicines (HIV regimen) that work by suppressing the replication of the virus. This reduces the amount of HIV in the body, known as viral load. HIV viral suppression is defined as less than 200 copies of HIV per milliliter of blood (2).

When this viral load is at undetectable levels (viral suppression), it doesn’t mean the virus is gone completely, but it does prevent the disease from progressing and means there is effectively no risk of passing HIV to others through sex (2). It also reduces the risk of transmission through shared needles and syringes, from a mother to her baby during pregnancy and at birth, and during breastfeeding. However, current recommendations in the United States state that HIV-positive mothers should not breastfeed their babies even if they have an undetectable viral load (2).

At the end of 2019, an estimated 59% of individuals on ART had achieved suppression of the HIV virus with no risk of transmitting the virus to others through sex (1).

It is important to remember that ART does not prevent the transmission of other STDs. So just because you or your partner are on ART, other safe sex practices are still important.

What are the HIV medicines in an HIV regimen?
There are seven classes of HIV medicines, which are classified based on how they fight HIV (3):

  • Non-nucleoside reverse transcriptase inhibitors (NNRTIs)
  • Nucleoside reverse transcriptase inhibitors (NRTIs)
  • Protease inhibitors (PIs)
  • Fusion inhibitors
  • CCR5 antagonists
  • Integrase strand transfer inhibitors (INSTIs)
  • Post-attachment inhibitors

HIV regimens can differ between individuals and are selected based on various factors, including possible side effects, potential drug interactions, and disease progression.

When to start ART?
ART should be started as soon as possible following an HIV diagnosis. It doesn’t matter how healthy you are or how long you have had HIV.

ART is life-long and must be taken as prescribed on a daily basis. If ART is not taken consistently, drug-resistant HIV strains can develop, meaning the medications will no longer be effective (2).

Routine viral load and CD4+ T cell monitoring are important to ensure that treatment is effective and maintaining viral load at undetectable levels in the blood (3).

If the treatment is discontinued, HIV will continue to replicate increasing the risk of HIV transmission and the disease can progress to AIDS (3).

What are the potential side effects of ART?
HIV medicines available nowadays generally cause fewer side effects than some HIV medicines used in the past (4). However, some people do still experience a range of side effects, which can include:

  • Nausea and vomiting
  • Diarrhea
  • Difficulty sleeping
  • Dry mouth
  • Headache
  • Rash
  • Dizziness
  • Fatigue
  • Pain

What other treatment options are there?
Methods are also available to reduce the risk of contracting HIV. Pre-exposure prophylaxis (PrEP) is a daily medication that individuals at high risk of HIV (e.g. partner of an HIV-positive person) can take to minimize their risk of HIV infection. There are currently two FDA-approved PrEP medications that reduce the risk of contracting HIV via sex by up to 99% (5).

Post-exposure prophylaxis (PEP) is an emergency medication that must be started within 72 hours of exposure. PEP is a short course of medication that reduces the risk of infection but should not be used to replace other HIV and STD prevention methods (6).

References:
1. HIV/AIDS. World Health Organization.
2. HIV Treatment. CDC. Reviewed May 2021.
3. HIV Treatment: The Basics. NIH.gov (Reviewed March 2020)
4. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV. Clinical Info. HIV.gov (Updated June 20201)
5. FDA approves second drug to prevent HIV infection as part of ongoing efforts to end the HIV epidemic. FDA News Release. (October 2019).
6. PEP (Post-Exposure Prophylaxis). CDC. (Reviewed May 2021)

Posted in HIV

Will using condoms prevent me catching an STD?

Consistent and correct use of male latex condoms does dramatically reduce the risk of transmitting STDs. However, condoms do not eliminate the risk of STD transmission.

How are STDs transmitted?
STDs, such as chlamydia, gonorrhea, and HIV, are usually transmitted through contact between infected secretions from the vagina or urethra and mucosal surfaces of the anus, vagina, urethra, or cervix. Syphilis, genital warts (herpes), and human papillomavirus (HPV) typically cause ulcers or sores in the genital area, and transmission can occur when the ulcer/sore comes into contact with a mucosal surface.

How do condoms reduce transmission?
Latex condoms effectively prevent the contact between infected secretions and mucosal surfaces of a sexual partner. However, condoms are not 100% effective, particularly if they are used incorrectly. In addition, they can be less effective at preventing the transmission of STDs that cause genital sores (e.g. syphilis), especially if the condom does not cover the sore.

What reduces the effectiveness of a condom?
There are many mistakes in using condoms that are actually more common than you might realize. These include using:

  • An expired condom, which increases the risk of breakage during sex
  • Teeth to open the condom pack. This can damage the condom and increase the risk of breakage.
  • A condom that is too tight. The semen needs somewhere to go!
  • A condom with air left at the tip. This can cause it to burst during sex.
  • A partially unrolled condom. It needs to be fully unrolled to fit properly and prevent slipping off during sex.
  • An oil-based lubricant. These can weaken the latex. Stick to water-based lubrication to increase comfort and reduce the risk of condom tearing during sex.

Tips for using condoms correctly
These are the dos and don’ts for condom use as recommended by the CDC (1):

  • DO use a condom every time you have sex.
  • DO put on a condom before having sex.
  • DO read the package and check the expiration date.
  • DO make sure there are no tears or defects.
  • DO store condoms in a cool, dry place.
  • DO use latex or polyurethane condoms.
  • DO use a water-based or silicone-based lubricant to prevent breakage.
  • DON’T store condoms in your wallet as heat and friction can damage them.
  • DON’T use nonoxynol-9 (a spermicide), as this can cause irritation.
  • DON’T use oil-based products like baby oil, lotion, petroleum jelly, or cooking oil because they will cause the condom to break.
  • DON’T use more than one condom at a time.
  • DON’T reuse a condom.

Do I still need to get tested even if I always use condoms?
Yes. Condoms unfortunately do not eliminate the risk of STD transmission. So if you think you have been exposed to an STD and/or you are experiencing potential STD symptoms, get an STD test to keep yourself and your sexual partners safe and healthy.

Routine STD screening is still recommended for sexually active individuals, particularly with multiple sexual partners, even if condoms are consistently used.

References:
1. External (sometimes called Male) Condom Use. CDC. June 21, 2021.

Hepatitis C Quick Facts

What is hepatitis C?
Hepatitis C is a virus that causes acute (short-term) infections in some individuals, but in most individuals, the virus remains in the body causing serious chronic (long-term) infection (1).

How does hepatitis C spread?
Hepatitis C is usually transmitted through exposure to blood from an infected individual (1).

  • The most common way is through sharing needles
  • Other potential sources of infection include:
    • At birth (~6% of infants of infected mothers)
    • Sexual intercourse (rare but more common in men who have sex with men)
    • Healthcare exposures
    • Blood transfusions and organ transplants (now very uncommon)
    • Unregulated tattoos or body piercings
    • Sharing personal items that have been in contact with infected blood (e.g. glucose monitors, razors)

What are the symptoms of hepatitis C?
Many individuals with an acute hepatitis C infection remain asymptomatic and are unaware they are infected. However, it is still possible for viral transmission to occur even in the absence of symptoms. Symptoms may appear 2-12 weeks post-exposure and include:

  • Yellowing of the skin or eyes
  • Lack of appetite
  • Diarrhea and vomiting
  • Fever
  • Dark urine
  • Joint pain

More than 50% of infected individuals go on to develop a chronic infection (2), which again often doesn’t cause any noticeable symptoms at least for quite a long period.

Over several decades, mild to severe liver disease develops in most affected individuals, including cirrhosis and liver cancer (3).

Several factors increase the risk of the development of cirrhosis in infected individuals, including being male, >50 years, increased alcohol consumption, hepatitis B or HIV coinfection, and immunosuppressive therapy (3). Chronic HCV infection is a common reason for a liver transplant in the United States (4).

Due to a general lack of symptoms, often individuals infected with hepatitis C are only diagnosed through screening for blood donation or during a routine health check-up (1).

Who is at risk of hepatitis C?
Groups that have an increased risk of hepatitis C include:

  • HIV-positive individuals
  • Injectable drug users
  • Individuals on hemodialysis
  • Healthcare workers
  • Children born to hepatitis C-positive mothers

How is hepatitis C diagnosed?
Hepatitis C diagnosis is by laboratory analyses from a blood sample. The initial test detects antibodies that are produced by the immune system of an infected individual in response to the hepatitis C infection. The presence of these antibodies indicates that an individual has either a current or past hepatitis C infection. Additional testing to detect hepatitis C virus RNA is required to diagnose an active infection and determine the viral load.

How is hepatitis C treated?
Hepatitis C is treated with antiviral medications to eliminate the virus from the body. Newly developed “direct-acting” antivirals have improved hepatitis C treatment considerably with fewer side effects and shorter treatment periods. Nowadays, over 90% of infected individuals can be cured with 8-12 weeks of oral therapy (5).

Effective treatment slows down the progression of inflammation and scarring of the liver and reduces the chances of liver cancer. However, antivirals do not help repair any tissue damage that has already occurred.

References:
1. Viral Hepatitis – Q&As from the Public. (2020, July). CDC.
2. Liang TJ, Rehermann B, Seef LB, & Hoofnagle JH. (2000) Pathogenesis, natural history, treatment, and prevention of hepatitis C. Ann Intern Med, 132(4), 296-305.
3. Thomas DL & Seef LB. (2005) Natural history of hepatitis C. Clin Liver Dis, 9(3), 383-398.
4. Definition & Facts of Liver Transplant. March 2017.
5. Initial Treatment of Adults with HCV Infection. August 2020.

Hepatitis B Quick Facts

What is hepatitis B?
Hepatitis B is a major global health problem that can cause both acute (short-term) and chronic (long-term) liver disease (1).

How does hepatitis B spread?
In regions of the world with the highest rates of hepatitis B, perinatal transmission (mother to child at birth) is the most common mode of transmission. Horizontal transmission (exposure to infected blood), especially from an infected child to an uninfected child under the age of five years is also common (1).

Hepatitis B can also spread through needle stick injury, tattooing, piercing, sharing drug needles and syringes, and other exposures to infected blood, saliva, vaginal, and seminal fluids. Sexual transmission can occur, with more common occurrences in men who have sex with men, heterosexuals with multiple sex partners, and sex workers (and their clients) (1).

What are the symptoms of hepatitis B?
Many individuals with acute hepatitis B remain asymptomatic and are unaware they are infected. However, it is still possible for viral transmission to occur even in the absence of symptoms. In symptomatic individuals, yellowing of the skin or eyes, nausea, vomiting, abdominal pain, dark urine, and fatigue can last several weeks or persist for up to six months (1).

In some individuals, hepatitis B can develop into a chronic infection. This is common in infants and young children but rare (less than 5%) in adults. Chronic hepatitis B can develop into cirrhosis or liver cancer (2). Symptoms can include:

  • Fatigue
  • Weakness
  • Lower leg swelling
  • Yellow skin
  • Fluid accumulation in the abdomen
  • Spider-like blood vessels on the skin
  • Nausea
  • Indigestion
  • Pain at the top right of the abdomen or in the right shoulder (referred pain)

Who is at risk of hepatitis B?
Groups that have an increased risk of hepatitis B include:

  • Children of hepatitis B-positive mothers
  • Individuals who frequently require blood or blood products
  • Dialysis patients
  • Incarcerated persons
  • Injectable drug users
  • Close contacts of hepatitis B-infected individuals
  • Individuals with multiple sexual partners
  • Healthcare workers

How is hepatitis B diagnosed?
Hepatitis B diagnosis is by laboratory analyses from a blood sample. The most commonly detected component is the hepatitis B surface antigen (HBsAg). This can be detected within 30 to 60 days after infection, and remains detectable during both acute and chronic infections.

How is hepatitis B treated?
There are no specific treatments for an acute infection. Maintaining an adequate nutritional and fluid intake is important, particularly as additional fluids may be lost through vomiting and diarrhea.

Medications are available for chronic hepatitis B, but only 10% to 40% of individuals with chronic hepatitis B will require treatment. These medications suppress the replication of HBV, thereby slowing the progression of cirrhosis and reducing the risk of liver cancer, but they generally do not cure an HBV infection, so must continue for life (1).

A very effective and safe vaccination for hepatitis B is available. This vaccine induces protective antibody levels in more than 95% of individuals, with protection lasting for at least 20 years and probably lifelong.

References:
1. Hepatitis B, World Health Organization. July 2020.

2. Hepatitis B Questions and Answers for Health Professionals. CDC. July 2020.

Trichomoniasis Quick Facts

What is trichomoniasis?
Trichomoniasis is a common sexually transmitted disease (STD) that is spread through sexual contact with the penis or vagina of an infected individual.

What causes trichomoniasis?
Trichomoniasis is caused by infection with a protozoan parasite called Trichomonas vaginalis (1).

What are the symptoms of trichomoniasis?
Only approximately 30% of infected individuals show symptoms with the majority remaining asymptomatic (2). Some individuals show symptoms 5 to 28 days post-exposure, while symptoms occur in others much later, or symptoms may disappear then reappear (3).

Symptoms in males can include:

  • Itching or irritation inside the penis
  • Painful burning sensation after urination or ejaculation
  • Increased urination
  • Abnormal discharge from the penis

Symptoms in females can include:

  • Itching or irritation of the vagina
  • Painful and more frequent urination
  • Endocervical bleeding
  • Abnormal vaginal discharge with an unpleasant odor

Trichomoniasis infections are associated with an increased risk of contracting other STDs, particularly a 2- to 3-fold increased risk of HIV (2).

Who is at risk of trichomoniasis?
Any sexually active individual is at risk of trichomoniasis. Factors that are associated with a higher prevalence of trichomoniasis in the United States include increased poverty level, lower educational level, and unmarried status (4).

How is trichomoniasis diagnosed?
Modern nucleic acid amplification testing (NAAT) provides the most sensitivity and specificity for a trichomoniasis diagnosis. These can be performed on vaginal swabs (either clinician- or patient-collected) or urine.

How is trichomoniasis treated?
Prescription antibiotics are an effective treatment for trichomoniasis. Repeat infections from sexual contact with an infected partner are common; hence treatment of all sexual partners should occur at the same time.

References:
1. Soper D (2004). “Trichomoniasis: under control or undercontrolled?” Am J Obstet Gynecol. 190(1), 281-90.

2. Trichomoniasis Fact Sheet. CDC. Feb 2020. 
3. Satterwhite CL, et al. (2013). Sexually transmitted infections among US women and men: Prevalence and incidence estimates, 2008. Sex Transm Dis, 40(3), 187-193.
4. 2015 Sexually Transmitted Diseases Treatment Guidelines, Trichomoniasis. CDC. June, 2015. 

Viral load and viral suppression. What do they mean?

HIV refers to the human immunodeficiency virus, which is a viral infection that targets the body’s immune system cells, such as macrophages, dendritic cells, and helper T cells (specifically CD4+ cells) (1). In the absence of effective treatment, the number of CD4+ cells declines, eventually leading to a loss of cell-mediated immunity and the development of acquired immunodeficiency syndrome (AIDS) (2).

Although there is no cure for HIV, there are very effective medicines available to prevent the progression of HIV and to prevent the transmission of HIV to others through sex.

These medicines, called antiretroviral therapy (ART), reduce the viral load, which refers to the amount of HIV in the body. Consistent use of ART keeps the viral load low and enables the immune system to recover and maintain a high CD4+ T cell count.

When the viral load is very low, it is referred to as viral suppression. HIV viral suppression is defined as less than 200 copies of HIV per milliliter of blood (3). This can also be called an “undetectable viral load”.

When this viral load is at undetectable levels (viral suppression), it doesn’t mean the virus is gone completely, but it does prevent the disease from progressing and means there is effectively no risk of passing HIV to others through sex (3). It also reduces the risk of transmission through shared needles and syringes, from a mother to her baby during pregnancy and at birth, and during breastfeeding. However, current recommendations in the United States state that HIV-positive mothers should not breastfeed their babies even if they have an undetectable viral load (3).

At the end of 2019, an estimated 59% of individuals on ART had achieved suppression of the HIV virus with no risk of transmitting the virus to others through sex (4).

ART is life-long and must be taken as prescribed on a daily basis. If ART is not taken consistently, drug-resistant HIV strains can develop, meaning the medications will no longer be effective (3).

Routine viral load and CD4+ T cell monitoring are important to ensure that treatment is effective and maintaining viral load at undetectable levels in the blood (5).

References:
1. Cunningham, AL, et al. (2010) Manipulation of dendritic cell function by viruses. Curr Opin Microbiol, 13 (4), 524-529.

2. Weiss RA. (1993) How does HIV cause AIDS? Science, 260 (5112), 1273-1279.
3. HIV Treatment. Reviewed May 2021. CDC.
4. HIV/AIDS. World Health Organization.
5. HIV Treatment: The Basics. (Reviewed March 2020)HIVinfo. NIH.gov.

Posted in HIV

The importance of STD tests

Sexually transmitted diseases (STDs) can also be known as sexually transmitted infections (STIs). They are infections that are usually spread from person to person during vaginal, anal, and oral sex. Many STDs are quite common but do not cause any symptoms, particularly in the early stages. However, despite being asymptomatic, infected individuals can still transmit the STD to any sexual partners. In addition, if the STD is left untreated, serious health complications can occur.

Have you been potentially exposed to an STD?
STDs can spread through vaginal, anal, or oral sex, and sometimes transmission can occur even with the correct use of a condom.

Are you experiencing potential symptoms of an STD?
These can include:

  • Sore or bumps in the genital area
  • Abnormal discharge from the penis or vagina
  • Painful and/or frequent urination
  • Itching, pain, and/or irritation in the penis, vagina, vulva, or anus
  • Flu-like symptoms

Of course, these symptoms can also be caused by something that is not an STD (e.g. a yeast infection) and many people with an STD do not actually experience any symptoms. The only way to be sure that you don’t have an STD is to get tested.

Testing is simple and easy.
Just a urine sample or finger-prick blood sample is all that is required. We offer STD testing from a sample collected in the privacy of your own home. The sample is then shipped to our fully accredited laboratory for very accurate testing using approved and validated testing procedures. Your results are quickly available in your secure online account.

Testing is important.
Many STDs can cause serious health complications if they are left untreated. For example, untreated chlamydia and gonorrhea infections in females can lead to pelvic inflammatory disease (PID), and PID-associated infertility, and chronic pelvic pain. Complications in males include epididymitis and prostatitis (1).

Some STD infections during pregnancy are particularly dangerous. For example, syphilis during pregnancy is associated with miscarriage, stillbirth, or infant death shortly after delivery in up to 40% of cases. Congenital syphilis occurs when an infected pregnant woman passes syphilis to her baby during pregnancy. For infected infants, treatment must begin immediately to prevent developmental delays, seizures, and other fatal complications (2).

In addition, if you have an STD (even if asymptomatic), it can increase the risk of contracting another STD, which may be more serious. For example, trichomoniasis infections are associated with a two to three-fold increased risk of HIV (3).

CDC recommendations for STD testing include (4):

  • Annual screening for chlamydia and gonorrhea in females 25 years and younger
  • Screening for chlamydia and gonorrhea during each pregnancy
  • Routine screening for chlamydia in men who have sex with men and high-prevalence settings
  • Annual screening for gonorrhea in males 25 years and younger
  • Screening for trichomoniasis in females with abnormal vaginal discharge
  • HIV testing at least once for everyone 13 – 64 years, with annual screening in higher-risk populations and screening during each pregnancy
  • Anybody potentially exposed to HIV should be tested immediately and again at six weeks, three months, and six months post-exposure
  • Hepatitis B testing in individuals born in countries with high prevalence, as well as during pregnancy and in high-risk populations
  • Hepatitis C testing at least once and during each pregnancy (except in populations where the prevalence of HCV is less than 0.1%), as well as routine testing in high-risk populations
  • Syphilis testing in anyone showing suggestive signs of syphilis, as well as during pregnancy and in high-risk populations

References:
1. Farley TA, Cohen DA, & Elkins W (2003). Asymptomatic sexually transmitted diseases: the case for screening. Prev Med, 36 (4), 502-509.

2. 2015 STD Treatment Guidelines Syphilis. CDC 2015, June 4.
3. Trichomoniasis Fact Sheet. CDC Feb 2020.
4. Workowski KA & Bolan GA (2015) Sexually Transmitted Diseases Treatment Guidelines, 2015. MMWR Recomm Rep, 64 (RR-03), 1-137.

Syphilis Quick Facts

What is syphilis?
Syphilis is a sexually transmitted disease, which has been called “The Great Pretender”, as symptoms can resemble other diseases. Syphilis is primarily transmitted during sexual contact, or during pregnancy or childbirth from an infected mother to her infant (1).

What causes syphilis?
Syphilis is caused by infection with the bacterium Treponema pallidum subspecies pallidum.

What are the symptoms of syphilis?
Untreated syphilis infections have four distinct stages.

Primary syphilis is characterized by a skin lesion, called a chancre, which appears 10-90 days after infection. It can be a single chancre or multiple chancres may form (1). Chancres last 3-6 weeks and health whether or not treatment is received. If untreated, the infection progresses to the secondary stage (2).

Skin rashes and/or lesions in the mouth, vagina, or anus occur during the secondary stage of infection. Additional symptoms in the secondary stage can include fever, sore throat, hair loss, weight loss, swollen lymph glands, headaches, muscle aches, and fatigue (1). Like the primary symptoms, secondary symptoms will also disappear whether or not treatment is received. However, the syphilis infection will progress to the latent stage if adequate treatment does not occur (2).

The latent stage is not associated with any symptoms, except the syphilis-causing bacterium is still present. During the early latent stage, transmission can still occur. The latent stage can last for many years, with 15-40% of untreated individuals developing tertiary syphilis (3).

In some cases, the latent stage progresses to a potentially fatal tertiary stage. This can occur 10-30 years or more after acquiring a syphilis infection. Multiple different organ systems can be affected including the brain, nerves, eyes, heart, liver, bones, and joints.

Who is at risk of syphilis?
The primary high-risk populations for syphilis are men who have sex with men, and HIV-positive individuals. Other high-risk populations include individuals who have been incarcerated, sex workers, and members of certain racial groups (4).

How is syphilis diagnosed?
Syphilis diagnosis is by two types of laboratory analyses of a blood sample – nontreponemal and treponemal tests. Both are required for an accurate diagnosis.

How is syphilis treated?
Primary, secondary, and early latent stage syphilis (infection within 2 years) is treated with a single intramuscular dose of Benzathine penicillin G. Late latent stage syphilis (more than 2 years after original infection) requires three intramuscular doses of Benzathine penicillin G at weekly intervals (5).

References:
1. Kent ME & Romanelli F (2008). Reexamining syphilis: an update on epidemiology, clinical manifestations, and management. Ann Pharma, 42 (2), 226-236.

2. Syphilis – CDC Fact Sheet (Detailed). (2017, January).
3. Peeling RW, et al. (2017). Syphilis. Nat Rev Dis Primers, 3(17073).
4. Schwenk TL (2016, June 9). Screening High-Risk Populations for Syphilis. NEJM Journal Watch.
5. Workowski KA & Bolan GA (2015) Sexually Transmitted Diseases Treatment Guidelines, 2015. MMWR Recomm Rep, 64 (RR-03), 1-137.

What is the difference between HIV and AIDS?

HIV refers to the human immunodeficiency virus, which is a viral infection that targets the body’s immune system. If HIV is untreated, it can progress to acquired immunodeficiency syndrome (AIDS) (1).

HIV can be transmitted through certain bodily fluids (blood, semen, pre-seminal fluid, vaginal and rectal fluids, and breast milk). HIV is most commonly spread through vaginal or anal sex, or sharing needles, syringes, and other drug equipment. It can also be spread from a mother to her baby during pregnancy, childbirth, or breastfeeding (2).

Although there is no cure for HIV, there are effective medications (antiretroviral therapy, ART) to control the virus infection. ART slows down the replication of the virus to stop the disease from progressing and also prevents transmission to others (2).

There are three typical stages of an HIV infection (3).

  • Acute infection is when HIV is most infectious, although many people may not show any symptoms or only mild symptoms that are easily confused with other illnesses.
  • The second stage can be known as chronic infection, clinical latency, or asymptomatic HIV infection, as most individuals do not show any symptoms.
  • However, if HIV is left untreated, the damage to the body’s immune system gradually gets worse and worse and leads to the third stage known as acquired immunodeficiency syndrome (AIDS).

AIDS occurs due to the serious damage to the immune system caused by HIV. Symptoms can include rapid weight loss, extreme fatigue, depression, pneumonia, and increased susceptibility to other infections such as tuberculosis, severe bacterial infections, and certain cancers.

HIV disease progression can vary widely. Typically, untreated HIV infections progress to AIDS in 8-10 years, but it can be shorter or longer for some people. Most of those with untreated AIDS only survive about three years or less, depending on opportunistic infections and cancers (2).

References:
1. Weiss RA. (1993) How does HIV cause AIDS? Science, 260 (5112), 1273-1279.

2. HIV/AIDS. World Health Organization.
3. Symptoms of HIV. Clinical Info HIV.gov. July 2020.

Posted in HIV